Scientific Program

Session 1: Bacterial Infections
Chair: Mihai Netea, Netherlands
Tuberculosis,
Lalita Ramakrishnan, United Kingdom
Trained immunity: a memory for innate host response,
Mihai Netea, Netherlands
The road to death: Caspases, cleavage, and pores,
Vishva Dixit, United States
Bacterial Metabolite Patterns of Pathogenesis in Intestinal Immunity,
Read Pukkila-Worley, United States

Selected Abstracts I 

Chair: Neal Silverman, United States

An Evolutionarily Conserved Mechanism of STING-mediated NF-κB Activation Involving the C-terminal α-helix of STING and the IKK-complex,
Anna Hvarregaard Christensen, Denmark
ACE2-dependent and -independent SARS-CoV-2 Entries Dictate Viral Replication and Inflammatory Response in Cells,
Rongfu Wang, United States
Dual Antiviral Mechanisms of Oligoadenylate Synthetase 1 in Driving Translational Shutdown and Protecting Interferon Production and its Consequences on Antimicrobial Innate Immunity,
Saumendra N Sarkar, United States

Selected Abstracts II 

Chair: Fiachra Humphries, United States

Molecular Mechanisms of Effector Recognition by the NLRP1B Inflammasome,
Andrew Sandstrom, United States
Acute Suppression of Mitochondrial ATP Production Prevents Apoptosis and Provides an Essential Signal for NLRP3 Inflammasome Activation,
Olaf Groß, Germany
NLRP3 is a Thermosensor That is Negatively Regulated by High Temperature,
Rebecca Clare Coll, United Kingdom

Keynote Lecture

Chair: Ann Marshak Rothstein, United States
Nucleoside Modified mRNA-LNP Therapeutics,
Drew Weissman, United States

Selected Abstracts III

Chair: Megan Orzalli, United States

Dysregulation of Treg Homeostasis by ADAR1 Deficiency and Chronic MDA5 Signaling,
Domnica Luca, Germany
Nuclear Degradation of cGAS Maintains Immune Homeostasis,
Pengbiao Xu, Switzerland
RNA Sensor-mediated Signaling Pathway Regulates the Expression of Type I Interferon and Chemokines in Vaginal Epithelial Cells Against Genital Herpes,
Xin Lai, Denmark

Session 5: Early life Immunity Sponsored by the PILOT Consortium
Chairs: Phillipp Henneke, Germany & Muzlifah Haniffa, United Kingdom
Development of cellular barrier immunity,
Phillipp Henneke, Germany
Life and Death of Alveolar Macrophages,
Manfred Kopf, Switzerland 
Identifying the cell-cell interactions constituting the blueprint of the macrophage niche,
Martin Guilliams, Belgium
The developing human immune system,
Muzlifah Haniffa, United Kingdom

Selected Abstracts IV

Chair: Isabella Rauch, United States

Regulation of Cell Death by the Metabolite Fumarate,
Fiachra Humphries, United States
MAP3K5 Regulation of GSDMD Post-Translational Modifications Dictates Pyroptotic Progression,
Iain D C Fraser, United States
MLKL's Executioner Domain is Released During Necroptosis Prior to its RIPK3-mediated Phosphorylation,
Michelle J Pan,United States
The Role of NINJ1 in {Mycobacterium tuberculosis}-infected Macrophages,
Ragnhild S. R. Sætra, Norway
IL-1α Promotes Intestinal Integrity During Murine Visceral Leishmaniasis to Prevent Microbiota Translocation and Damppening Chronic Th1-inflammation,
Vanessa Carregaro Pereira, Brazil
NAIP—NLRC4 Inflammasome Activation in Tuft Cells Activates a PGD2-ILC3 Signaling Circuit That Can Protect Against Enteric Infection,
Isabella Rauch, United States

Session 7: Viral Immunity
Chairs: Veit Hornung, Germany
Innate immune control of emerging RNA viruses,
Sara Cherry, United States
Innate immune signaling pathways control Zika virus infection in the placenta and viral persistence in the mother,
Mike Diamond, United States
Regulatory Mechanisms of Virus Infection and Immunity,
Michaela Gack, United States
Human innate immune driven disease in nextGEN humanized mice,
Richard Flavell, United States

Selected Abstract V

Chair: Susan Carpenter, United States

Peroxisome Lipid Metabolism Orchestrates Inflammatory Pathways From Fly to Humans,
Francesca Di Cara, Canada
Cardiolipin as Caspase-4/11 Inhibitor: Bacteria Immune Escape or Host Ally in Sepsis?
Malvina Pizzuto, Australia
FADD Integrates Independent STING and IMD Signaling to Control Caspase-mediated NF-κB Activation in Drosophila Melanogaster,
Kasper Grønbjerg Winther, France
Differential Signaling Between TLR7 and TLR9 That Controls Lupus is Genetically Mapped to Their Respective TIR Domains,
Claire Leibler, France
Toll Regulates Epithelial Renewal in the "{"Drosophila"}" Gut,
Petros Ligoxygakis, United Kingdom
SLAMF1-derived Peptide Inhibits Signaling initiated by Endosomal Toll-like Receptors,
Maria Yurchenko, Norway
Bacterial ADP-heptose Initiates a Revival Stem Cell Program in the Intestinal Epithelium,
Shawn Goyal, Canada
High Throughout Identification and Characterization of Functional lncRNAs in Innate Immunity,
Susan Carpenter, United States

Industry Session: Translational Development of TLR Pathway Modulators
Chair: Ofer Levy, United States
Precision Adjuvants: Bringing Precision Medicine to Adjuvant Science, Ofer Levy, United States
Clinical evaluation of synthetic TLR4 and TLR7/8 ligands in immunotherapy, Jay Evans, United States

Luncheon Session: Meet the Editors

Chairs: Zoltan Fehervari, Springer Nature & Cheri Sirois, Cell Press

An Inflammasome Safeguard in Premalignancy,

Keynote Lecture

Chair: Douglas Golenbock, United States
The intersection of innate immune receptors and adaptive immunity,
Jenny Ting, United States