Scientific Program


Legends Plenary Sessions
Selected Abstracts Sessions
Industry Sessions
Luncheon Session
17 April, Wednesday

STARTEndPlenary Hall
Willem Burger Zaal

Session 1: Bacterial Infections
Chair: Mihai Netea, Netherlands
Lalita Ramakrishnan, United Kingdom
Trained immunity: a memory for innate host response,
Mihai Netea, Netherlands
The road to death: Caspases, cleavage, and pores,
Vishva Dixit, United States
Bacterial Metabolite Patterns of Pathogenesis in Intestinal Immunity,
Read Pukkila-Worley, United States


Selected Abstracts I 

Chair: Neal Silverman, United States

An Evolutionarily Conserved Mechanism of STING-mediated NF-κB Activation Involving the C-terminal α-helix of STING and the IKK-complex,
Anna Hvarregaard Christensen, Denmark
ACE2-dependent and -independent SARS-CoV-2 Entries Dictate Viral Replication and Inflammatory Response in Cells,
Rongfu Wang, United States
Dual Antiviral Mechanisms of Oligoadenylate Synthetase 1 in Driving Translational Shutdown and Protecting Interferon Production and its Consequences on Antimicrobial Innate Immunity,
Saumendra N Sarkar, United States

15:2515:45Coffee Break
15:4517:25Session 2: Innate Immunity at the Barrier
Chair: Trude Flo, Norway
Role of SLC46s in Cytosolic Innate Immune Recognition,
Neal Silverman, United States
Innate Defense at Barriers,
Ramnik Xavier, United States
Phagocytosis, new technologies, receptors, and surprises,
David Underhill, United States
Regulation of Cutaneous Antiviral Immunity,
Megan Orzalli, United States

Selected Abstracts II 

Chair: Fiachra Humphries, United States

Molecular Mechanisms of Effector Recognition by the NLRP1B Inflammasome,
Andrew Sandstrom, United States
Acute Suppression of Mitochondrial ATP Production Prevents Apoptosis and Provides an Essential Signal for NLRP3 Inflammasome Activation,
Olaf Groß, Germany
NLRP3 is a Thermosensor That is Negatively Regulated by High Temperature,
Rebecca Clare Coll, United Kingdom

17:5518:15Coffee Break

Keynote Lecture

Chair: Ann Marshak Rothstein, United States
Nucleoside Modified mRNA-LNP Therapeutics,
Drew Weissman, United States

19:0020:00Welcome Reception / Poster Session

18 April, Thursday

STARTENDPlenary Hall
Willem Burger Zaal
09:0010:15Session 3: Effector Mechanisms
Chair: Clare Bryant, United Kingdom
Layers of immunity: Deconstructing the Drosophila effector response,
Bruno Lemaitre, Switzerland
The Gonococcus Evades Host Defenses by Exploiting an Interferon Epsilon-dependent Reservoir of Sialic Acid,
Douglas Golenbock, United States
Structures and functions in Innate Immunity,
Hao Wu, United States

Selected Abstracts III

Chair: Megan Orzalli, United States

Dysregulation of Treg Homeostasis by ADAR1 Deficiency and Chronic MDA5 Signaling,
Domnica Luca, Germany
Nuclear Degradation of cGAS Maintains Immune Homeostasis,
Pengbiao Xu, Switzerland
RNA Sensor-mediated Signaling Pathway Regulates the Expression of Type I Interferon and Chemokines in Vaginal Epithelial Cells Against Genital Herpes,
Xin Lai, Denmark

10:4511:05Coffee Break
11:0513:10Session 4: Metabolism
Chair: Luke O'Neill, Ireland
A break in mitochondrial endosymbiosis as a basis for inflammatory diseases,
Luke O'Neill, Ireland

Metabolite Signaling in Macrophages as a Regulator of Thermogenesis,
Evana Mills, United States

Innate & Inflammasomes,
Eicke Latz, Germany
IRG1-itaconate Axis in Lipid Homeostasis and Atherosclerosis,
Kathryn Moore, United States
Immune-mediated reprogramming of host energy metabolism in malaria,
Ricardo Gazzinelli, Brazil
13:1014:00Lunch Break

Session 5: Early life Immunity Sponsored by the PILOT Consortium
Chairs: Phillipp Henneke, Germany & Muzlifah Haniffa, United Kingdom
Development of cellular barrier immunity,
Phillipp Henneke, Germany
Life and Death of Alveolar Macrophages,
Manfred Kopf, Switzerland 
Identifying the cell-cell interactions constituting the blueprint of the macrophage niche,
Martin Guilliams, Belgium
The developing human immune system,
Muzlifah Haniffa, United Kingdom


Selected Abstracts IV

Chair: Isabella Rauch, United States

Regulation of Cell Death by the Metabolite Fumarate,
Fiachra Humphries, United States
MAP3K5 Regulation of GSDMD Post-Translational Modifications Dictates Pyroptotic Progression,
Iain D C Fraser, United States
MLKL's Executioner Domain is Released During Necroptosis Prior to its RIPK3-mediated Phosphorylation,
Michelle J Pan,United States
The Role of NINJ1 in {Mycobacterium tuberculosis}-infected Macrophages,
Ragnhild S. R. Sætra, Norway
IL-1α Promotes Intestinal Integrity During Murine Visceral Leishmaniasis to Prevent Microbiota Translocation and Damppening Chronic Th1-inflammation,
Vanessa Carregaro Pereira, Brazil
NAIP—NLRC4 Inflammasome Activation in Tuft Cells Activates a PGD2-ILC3 Signaling Circuit That Can Protect Against Enteric Infection,
Isabella Rauch, United States

16:4017:00Coffee Break
17:0018:40Session 6: TLRs & PRRs
Chair: Eicke Latz, Germany
Nucleic acid recognition by Toll-like receptors,
Greg Barton, United States
Regulation of Cell Death and Inflammation via RIPK1/caspase-8,
Egil Lien, United States
Endosomal vs Cytosolic Nucleic Acid Sensors in Autoinflammation,
Ann Marshak Rothstein, United States
Genetic Dissection of the TLR Paradox in Lupus: Implications for endosomal TLR function,
Mark Shlomchik, United States
19:3022:00Speaker's Dinner @ Euromast (Invitation Only)

19 April, Friday

STARTEndPlenary Hall
Willem Burger Zaal

Session 7: Viral Immunity
Chairs: Veit Hornung, Germany
Innate immune control of emerging RNA viruses,
Sara Cherry, United States
Innate immune signaling pathways control Zika virus infection in the placenta and viral persistence in the mother,
Mike Diamond, United States
Regulatory Mechanisms of Virus Infection and Immunity,
Michaela Gack, United States
Human innate immune driven disease in nextGEN humanized mice,
Richard Flavell, United States

10:4011:00Coffee Break

Selected Abstract V

Chair: Susan Carpenter, United States

Peroxisome Lipid Metabolism Orchestrates Inflammatory Pathways From Fly to Humans,
Francesca Di Cara, Canada
Cardiolipin as Caspase-4/11 Inhibitor: Bacteria Immune Escape or Host Ally in Sepsis?
Malvina Pizzuto, Australia
FADD Integrates Independent STING and IMD Signaling to Control Caspase-mediated NF-κB Activation in Drosophila Melanogaster,
Kasper Grønbjerg Winther, France
Differential Signaling Between TLR7 and TLR9 That Controls Lupus is Genetically Mapped to Their Respective TIR Domains,
Claire Leibler, France
Toll Regulates Epithelial Renewal in the "{"Drosophila"}" Gut,
Petros Ligoxygakis, United Kingdom
SLAMF1-derived Peptide Inhibits Signaling initiated by Endosomal Toll-like Receptors,
Maria Yurchenko, Norway
Bacterial ADP-heptose Initiates a Revival Stem Cell Program in the Intestinal Epithelium,
Shawn Goyal, Canada
High Throughout Identification and Characterization of Functional lncRNAs in Innate Immunity,
Susan Carpenter, United States


Industry Session: Translational Development of TLR Pathway Modulators
Chair: Ofer Levy, United States
Precision Adjuvants: Bringing Precision Medicine to Adjuvant Science, Ofer Levy, United States
Clinical evaluation of synthetic TLR4 and TLR7/8 ligands in immunotherapy, Jay Evans, United States


20 April, Saturday

STARTEndPlenary Hall
Willem Burger Zaal
09:0010:40Session 8: NLRs
Chair: Thirumala-Devi Kanneganti, United States
Recognition of nucleic acids by Toll-like receptors,
Veit Hornung, Germany
Effector-triggered immunity,
Russell Vance, United States
NLRP3 inflammasome activation drives neurodegeneration in Alzheimer's disease,
Michael Heneka, Luxembourg
Changing paradigms in Pattern Recognition Receptor signaling,
Clare Bryant, United Kingdom
10:4011:00Coffee Break
11:0012:40Session 9: Cell Death
Chair: Egil Lien, United States
Programmed necrotic cell death as a driver of inflammation,
Petr Broz, Switzerland
A Tale of Two Inflammasome in Human Skin Cells,
Franklin Zhong, Singapore
Regulation of Innate Immunity,
Jonathan Kagan, United States
Barrier-cell Inflammasome Activation and Pyroptosis in Anti-bacterial Defense and Sepsis,
Feng Shao, China
12:4013:40Lunch Break

Luncheon Session: Meet the Editors

Chairs: Zoltan Fehervari, Springer Nature & Cheri Sirois, Cell Press

13:4015:20Session 10: DAMPs
Chair: Kenneth L. Rock, United States
Discovery of a novel & unique human DAMP receptor, its ligand, and role in inflammation,
Kenneth Rock, United States
DaNGeRous necrophagy, coprohagy and immunity to cancer,
Caetano Reis e Sousa, United Kingdom
Innate immune response of phagocytes to PAMPs and DAMPs,
Ivan Zanoni, United States
Molecular mechanisms of innate immunity and inflammation in health and disease,
Thirumala-Devi Kanneganti, United States
15:2015:40Coffee Break
15:4017:20Session 11: Intracellular Signaling
Chair: Kate Fitzgerald, United States
Blown Apart: Mitochondrial Damage in Pyroptosis,
Judy Lieberman, United States
Revving up immune response with cGAS,
James Chen, United States

An Inflammasome Safeguard in Premalignancy,

Julie Magarian Blander, United States
Regulation of Innate Immunity,
Kate Fitzgerald, United States

Keynote Lecture

Chair: Douglas Golenbock, United States
The intersection of innate immune receptors and adaptive immunity,
Jenny Ting, United States

20:00LATETOLL NIGHT@ SS Rotherdam